Retroviral Recombination In Vivo: Viral Replication Patterns and Genetic Structure of Simian Immunodeficiency Virus (SIV) Populations in Rhesus Macaques after Simultaneous or Sequential Intravaginal Inoculation with SIVmac239 vpx/ vpr and SIVmac239 nef
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چکیده
Retroviral Recombination In Vivo: Viral Replication Patterns and Genetic Structure of Simian Immunodeficiency Virus (SIV) Populations in Rhesus Macaques after Simultaneous or Sequential Intravaginal Inoculation with SIVmac239 vpx/ vpr and SIVmac239 nef Eun-Young Kim, Marc Busch, Kristina Abel, Linda Fritts, Patty Bustamante, Jenny Stanton, Ding Lu, Samuel Wu, Jenny Glowczwskie, Tracy Rourke, Derek Bogdan, Mike Piatak, Jr., Jeffrey D. Lifson, Ronald C. Desrosiers, Steven Wolinsky, and Christopher J. Miller* Division of Infectious Diseases, The Feinberg School of Medicine at Northwestern University, Chicago, Illinois; Center for Comparative Medicine, California National Primate Research Center, and Division of Infectious Diseases, School of Medicine, University of California, Davis, Davis, California; AIDS Vaccine Program, SAIC Frederick, Inc., NCI—Frederick, Frederick, Maryland; and New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts
منابع مشابه
Direct demonstration of retroviral recombination in a rhesus monkey.
Recombination may be an important mechanism for increasing variation in retroviral populations. Retroviral recombination has been demonstrated in tissue culture systems by artificially creating doubly infected cells. Evidence for retroviral recombination in vivo is indirect and is based principally on the identification of apparently mosaic human immunodeficiency virus type 1 genomes from phylo...
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